Norwich scientists say home urine test could 'revolutionise' prostate cancer diagnosis

Marco Green
December 1, 2019

Researchers say the test will be more sensitive than current methods and will be in the form of a collection kit that will enable people to do a urine test in the comfort of their own home.

Having the option to do a home test pack is a stage forward on the grounds that it could spell the finish of awkward rectal tests.

"For the reason that PUR take a look at correctly predicts competitive prostate most cancers and predicts whether or not sufferers would require remedy as much as 5 years previous than same old medical strategies - it implies that a destructive take a look at may just allow males to simply be retested each two to 3 years, relieving rigidity to the affected person and lowering clinic workload", added Clark.

A home urine test could "revolutionise" prostate cancer diagnosis for thousands of men.

"It capacity that men wouldn't must undergo a digital rectal examination, so it would possibly per chance presumably well per chance be noteworthy less stressful and would possibly presumably well simply discontinuance in plenty extra patients being tested".

"We developed the PUR test, which looks at gene expression in urine samples and provides vital information about whether a cancer is aggressive or "low risk". They then when compared the result of their domestic urine samples, taken very first thing within the morning, with samples amassed after a virtual rectal exam.

The "home collection kit" would mean men don't have to visit a clinic - or have to undergo an uncomfortable examination.

Sex hormone androgen is the main driver of prostate cancer, so hormone therapy to suppress his or its receptor, the so-called chemical castration is the standard frontline therapy.

Robert Mills, Consultant Surgeon in Urology at the Norfolk and Norwich University Hospital, said: "This is a very exciting development as this test gives us the possibility of differentiating those who do from those who do not have prostate cancer so avoiding putting a lot of men through unnecessary investigations".

If the man is deemed at risk, they will be referred to hospital to discuss the options of further tests, which include an MRI and biopsy.

'And feedback from the participants showed the at home test was preferable'.

Lead researcher Dr Jeremy Clark, from UEA's Norwich Medical School, said: "Prostate cancer is the most common cancer in men in the UK".

An immunotherapy drug in a major trial has shown to be effective in some men suffering from advanced prostate cancer, according to a media report said.

Active surveillance, or "watchful waiting" is a way of monitoring prostate cancer that isn't causing any symptoms or problems over the long term. "That is against this to the present scenario the place males are recalled to the health center each six to 12 months for painful and costly biopsies", persevered Clark.

Dr Clark said: 'The PUR test accurately predicts aggressive prostate cancer, and predicts whether patients will require treatment up to five years earlier than standard clinical methods.

For these men, the test could cut follow-up appointments from once every year to once every two to three years.

Ray Cossey, trustee of the Norfolk and Waveney Prostate Cancer Support Group, described the new test as the "holy grail" of prostate cancer diagnosis.

"This urine test has the potential to tell us whether we needed to intervene with these patients".

Dr Mangesh Thorat, from King's College London, said: "This is misleading and overstates the case".

'Be that as it may, these pee based biomarkers, albeit promising and a zone of dynamic research, are not yet suggested for prostate malignant growth screening or during the executives of prostate disease by dynamic observation.

'Therefore, these findings do not now have any clinical or public health implications.

There is no national prostate screening program with respect to years the tests have been excessively off base.

Men over 50 in the United Kingdom can opt to have their protein specific antigen (PSA) levels tested, however, this is controversial. But it is unreliable.

The findings, published in BioTechniques, could also help pioneer the development of home tests for bladder or kidney cancer.

'This new test is from the get-go in its advancement, however can possibly offer a basic, non-intrusive method for anticipating forceful prostate disease without the requirement for men to go to a center.

The Norfolk and Norwich University Hospital receives more than 800 referrals a year to investigate and treat potential prostate cancers.

■ THE number of cancer sufferers in the United Kingdom has risen by almost a fifth in five years to nearly 3million.

Prostate cancer became a bigger killer than breast cancer for the first time, official statistics revealed a year ago.

Other reports by Click Lancashire

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