Ronaldo sent off; will miss United return

After Murillo went down inside the area, the Portugal forward gestured for his opponent to get up, then put his hand on the Valencia defender's head and appeared to tug his hair.

Jose Mourinho's side host their Italian rivals on the third match day on October 23 before heading to Turin two weeks later.

Rio Ferdinand was one of many to react to the decision, tweeting that Ronaldo should appeal and also discussing the episode during his duties as a pundit.

It was the first red card in the Champions League in Ronaldo's career, in his 154th appearance.

Ronaldo scored in United's 2-0 win away to Aston Villa on the final day of the season, but was booked twice for diving and time wasting late on.

After all, the sending off could see him miss a huge game with Manchester United that would prove a crucial match in the group stages as well as a fairytale reunion.

To add insult to injury, a first half substitution happened after Khedira, guilty of a big miss seconds ago, struggled to continue after picking a hamstring and was replaced by Emre Can on 22 minutes.

Pjanic stepped up once again and made no mistake from the spot.

Despite the numerical advantage, Valencia posed little threat going forward but nearly grabbed a consolation in stoppage time when it was given a penalty of its own.

German side Hoffenheim and Shakhtar Donetsk shared an entertaining 2-2 draw in Ukraine in the other Group H clash.

Real Madrid got their title defence off to a strong start by convincingly beating Roma 3-0 at home.

Gareth Bale doubled the lead on 58 minutes and a stoppage-time strike from returning striker Mariano Diaz rounded out the scoring at the Bernabeu.